IC-3Rs • Innovation Centre for 3R Alternatives

IC-3Rs News

TADA Workshop

by IC-3Rs

In November, IC-3Rs was invited by TADA to whisk more than 30 curious kids into the world of the 3Rs! Together, we put on our lab coats and gloves for a hands-on experiment and discovered how fun alternative methods can be. Watching the children’s eyes lighting up during the workshop is always the most rewarding part of the day — who knows, maybe a future NAM scientist was sitting in the room, already dreaming big. Let’s keep sparking bright minds and shaping the 3Rs future together!

IC-3Rs Symposium 2025

by IC-3Rs

This September, we proudly hosted the 8th edition of the IC-3Rs Symposium, themed “Tools in Action: Driving Better 3Rs Science.” The event was fully booked, welcoming more than 200 leading experts, young researchers, and industry partners for a full day of scientific exchange focused on concrete, high-impact tools that are shaping the future of science and the advancement of the 3Rs. We were honoured to feature an exceptional lineup of speakers who presented some examples of the 3Rs in action from advanced multi-organ-on-chip models (Reyk Horland), next-generation risk assessment strategies for skin sensitization of feminine products (Quinten Marcelis), database for animal-free antibodies (Esther Wenzel) and virtual control groups (Thomas Steger-Hartmann) to VR in equine surgery (Dimitri Kadic), AI powered pain scoring in animals (Albert Ali Salah) and an update on the RE-Place database (Maude Everaert). A special congratulations goes to Bieke Bekaert, winner of the poster competition, for her outstanding work entitled:: “Efficient evaluation of therapeutic compounds for Charcot-Marie-Tooth disease using patient-derived neuromuscular organoids.”

We also applaud all young scientists who presented posters — your enthusiasm and research excellence enriched the symposium. We are already looking forward to the next edition of the IC-3Rs Symposium.

WC13 Brasil

by IC-3Rs

At WC13 in Brasil, IC‑3Rs was well represented: we presented more than three posters during the poster sessions. The central theme of WC13, “3Rs Integrating 3 Worlds: Human, Animal and Environmental Health”, eloquently underlined a vision for the coming decade: doing research guided by the principle of One Health, ensuring safety both for humans, animals and the environment. A major highlight of the congress was the emphasis on bringing together traditional animal-research communities and researchers working with NAMs. This gathering underscored the importance of creating a shared scientific language that bridges disciplines — a crucial step if we want to move research forward in a unified, coherent way. It was inspiring to learn what other 3Rs-centres — even those on the other side of the world — are doing, and to understand the different challenges they face. Such global exchange sparks new ideas and strengthens the worldwide 3Rs community. We believe our participation helped contribute to this growing international dialogue, and we look forward to connecting again soon — hopefully at the next WC13 meeting in Seoul.

NAMii Webinar Series

by IC-3Rs

Twelve New Approach Methodologies (NAM) information initiatives – together under the name NAMii – have joined forces to organise an inspiring webinar series. This webinar series, a joint effort by ZonMw (Netherlands Organisation for Health Research and Development) and RIVM (National Institute for Public Health and the Environment), aims to highlight information initiatives related to NAMs. The focus will be on showcasing tools—including knowledge bases, search engines, and infrastructures—that can help improve the efficiency and effectiveness of your NAM-based research. The series is scheduled to run from October 2025 to March 2026. Webinars will be held on Thursdays from 12:00 to 13:00 CET.

Join the NAM expert pool database from COST Action IMPROVE

by IC-3Rs

The EU COST Action IMPROVE consortium is establishing a database that contains experts on New Approach Methodologies (NAMs). NAMs include any technology or model – in vitroin silico, in chemico, alternative in vivo models and other technologies such as omics – that does not rely on the use of animals. With the rapid increase in technological possibilities and the ensuing vast expanse in NAMs, it is increasingly hard to evaluate whether alternative methods for proposed animal experiments do exist or are indeed lacking.

As a recognized expert in NAMs, the COST Action IMPROVE invites you to register yourself in their database. Participating 3Rs Centres can have access to the database upon request. Experts who agree to be included in the database may be further contacted for collaboration/consultation/project evaluations (e.g. in the context of evaluating whether proposed animal testing is necessary and whether (no) alternatives (NAMs) exist). Inclusion in the database is entirely voluntary. 

RE-Place Award at MPS

by IC-3Rs

During the MPS 2025 organised from 9 to 13 June 2025 in Brussels, the RE-Place team granted the RE-Place Best Poster Presentation award. The prize was open to PhD students and early career investigators presenting their research in the field of 3R replacement methodologies. Emma Streutker, a PhD student at the Radboud Institute for Molecular Life Sciences, was awarded the prize for her poster titled A fibrosis-on-chip model to study Systemic Sclerosis.” Her work was recognized for its scientific excellence, impactful results, and the clarity of her presentation.

RE-Place user survey

by IC-3Rs

A short RE-Place user survey has recently been launched to gain insights into how the website and database are being used. The feedback collected will help to improve the platform, assess its impact, and ensure it better meets the needs of the research community in Belgium.

Researchers, visitors, and contributors alike are encouraged to participate—whether they have used the platform, visited the site, or added a method to the database. Completing the survey takes only a few minutes.

Workshop Niet-Technische Samenvatting (NTS)

by IC-3Rs

Wil je leren hoe je een niet-technische samenvatting (NTS) schrijft die transparantie in proefdieronderzoek maximaliseert? De European Animal Research Association (EARA), met steun van IC-3Rs, organiseert een interactieve workshop voor iedereen die NTS’en opstelt of beoordeelt. Er zijn nog enkele plekken vrij dus bij interesse, schrijf je snel in!

Waarom deelnemen?
✔ Begrijp de rol en wettelijke vereisten van NTS
✔ Leer complexe wetenschap helder en toegankelijk te verwoorden
✔ Ontvang praktische tips en oefen met sjablonen en online tools

📅 22/05/2025 📍 VUB, Campus Jette  13u - 17u 🗣️ De workshop wordt gegeven in het Nederlands

⚠️ Beperkt aantal plaatsen! Registratie betekent niet automatisch deelname. Na inschrijving ontvangen geselecteerde deelnemers een bevestiging en officiële uitnodiging.

New database non-animal derived antibodies

by IC-3Rs

A major step forward in promoting the use of non-animal derived antibodies has been taken with the launch of the Recombinant Antibodies and Mimetics Database, developed by the Centre for Human Specific Research.

This user-friendly, first-of-its-kind resource categorises recombinant antibodies and antibody mimetics based on their origin, discovery, and production methods, using a clear colour-coding system to indicate the involvement of animals or animal-derived biomaterials in the manufacturing process.

Currently featuring thousands of entries and expanding regularly, the database serves as a valuable tool for researchers, Animal Welfare Bodies, National Committees, and others seeking replacement opportunities in line with the 3Rs.